Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases


Induced pluripotent stem cells (iPSCs) hold great promise to model diseases, where the disease affected cell type is difficult to access. A major obstacle for the development of disease models is the lack of well characterized control iPSCs from old people not affected by such a disease. Furthermore, gene-editing approaches often require iPSCs from healthy donors, where pathogenic mutations can be inserted if patient material is not available. Here, we report the generation of an iPSC line (16423 #6) from a 77-year-old woman, who did not display any disease symptoms at the time, when the skin biopsy was taken. Copyright © 2016 Michael Boutros, German Cancer Research Center, Heidelberg, Germany. Published by Elsevier B.V. All rights reserved.

Authors Nimsanor N, Jørring I, Rasmussen MA, Clausen C, Mau-Holzmann UA, Bus C, Hoffmann SA, Gasser T, Kluba T, Holst B, Schmid B
Journal Stem cell research
Publication Date 2016 Nov;17(3):550-552
PubMed 27789407
DOI 10.1016/j.scr.2016.09.019

Research Projects

Cell Lines