Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases
Summary
Induced pluripotent stem cells (iPSCs) hold great promise to model diseases, where the disease affected cell type is difficult to access. A major obstacle for the development of disease models is the lack of well characterized control iPSCs from old people not affected by such a disease. Furthermore, gene-editing approaches often require iPSCs from healthy donors, where pathogenic mutations can be inserted if patient material is not available. Here, we report the generation of an iPSC line (16423 #6) from a 77-year-old woman, who did not display any disease symptoms at the time, when the skin biopsy was taken. Copyright © 2016 Michael Boutros, German Cancer Research Center, Heidelberg, Germany. Published by Elsevier B.V. All rights reserved.
| Authors | Nimsanor N, Jørring I, Rasmussen MA, Clausen C, Mau-Holzmann UA, Bus C, Hoffmann SA, Gasser T, Kluba T, Holst B, Schmid B |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2016 Nov;17(3):550-552 |
| PubMed | 27789407 |
| DOI | 10.1016/j.scr.2016.09.019 |