Generation of an iPSC line (IMAGINi011-A) from a patient carrying a STING mutation
Summary
Mutation in STING1gene, which encodes stimulator of type I IFN gene (STING) leads to its constitutive activation and thereby to a severe vasculopathy and sometimes a lupus-like disease. We generated induced pluripotent stem cells (iPSCs) from a patient carrying a rare heterozygous variant c.463G > A (resulting in a p.V155M substitution) in STING1. Cells from this patient, which were reprogrammed by non-integrative viral transduction, had normal karyotype, expressed pluripotency markers and were able to differentiate into the three germ cell layers. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Barnabei L, Castela M, Banal C, Lefort N, Rieux-Laucat F |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec 2;50:102107 |
| PubMed | 33340797 |
| DOI | 10.1016/j.scr.2020.102107 |