Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation
Summary
We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Hernández D, Morgan Schlicht S, Elli Clarke J, Daniszewski M, Karch CM, Dominantly Inherited Alzheimer Network (DIAN), Goate AM, Pébay A |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Sep;79:103495 |
| PubMed | 39079290 |
| PubMed Central | PMC11608089 |
| DOI | 10.1016/j.scr.2024.103495 |