Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
Summary
We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. This new model might serve as a preclinical tool to test antiarrhythmic drugs increasing the insight in treating ventricular tachycardia. © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.
| Authors | Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T |
|---|---|
| Journal | Cardiovascular research |
| Publication Date | 2020 Jul 1;116(8):1487-1499 |
| PubMed | 31598634 |
| PubMed Central | PMC7314638 |
| DOI | 10.1093/cvr/cvz245 |