Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue


We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. This new model might serve as a preclinical tool to test antiarrhythmic drugs increasing the insight in treating ventricular tachycardia. © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.

Authors Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T
Journal Cardiovascular research
Publication Date 2020 Jul 1;116(8):1487-1499
PubMed 31598634
PubMed Central PMC7314638
DOI 10.1093/cvr/cvz245

Research Projects

Cell Lines