Generation of a human induced pluripotent stem cell line (YUCMi020-A) from peripheral blood mononuclear cells derived from a female with the Jr(a-) blood type
Summary
The Jra antigen, the only antigen within the JR blood group system, is a high-prevalence red blood cell (RBC) antigen found in over 99 % of the global population. An induced pluripotent stem cell line (YUCMi020-A) was generated from peripheral blood drawn from a Jr(a-) phenotype individual, who was homozygous for a null mutation of ABCG2*01N.01 (rs72552713, c.376C>T; p.Gln126*). The generated line exhibited pluripotent characteristics and no chromosomal aberrations. This cell line will serve as a cell source, enabling us to produce RBCs with the Jr(a-) phenotype in vitro, which can be used for transfusing individuals with anti-Jra antibodies. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Cho YK, Kim HK, Suh EJ, Kim HO, Kim S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Jun;77:103434 |
| PubMed | 38703667 |
| DOI | 10.1016/j.scr.2024.103434 |