Generation of induced pluripotent stem cell line (KRIBBi004-A) from adult bone marrow CD34(+) cells from a patient carrying 46,XX,t(1;5)(p31.1;35.1) karyotype


Induced pluripotent stem cell (iPS) technology may be advantageous for the study of genetic aberrations in terms of recapitulating the full manifestation of pathological features in vitro, identifying underlying pathways, and developing personalized therapeutics rather than procuring somatic cells from patients. Here, we derived an iPSC line from a patient with reciprocal chromosome translocation, t(1;5)(p31.1;35.1), as a novel alternative model to identify clinical phenotypes induced by genetic instability. The resulting iPSC line generated from somatic cells with an existing instability showed representative characteristics of PSCs, and might serve as an unparalleled cellular resource for the development of a custom remedy. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Koh H, Kwon SY, Zhen X, Ha HY, Lee JH
Journal Stem cell research
Publication Date 2021 Dec;57:102587
PubMed 34736040
DOI 10.1016/j.scr.2021.102587

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