Generation of an induced pluripotent stem cell line AMUFAHi002-A from polycystic ovary syndrome patient


Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in women of reproductive age. The PCOS leads to obesity, dyslipidemia, insulin resistance, hyperandrogenism, and infertility. We established an induced pluripotent stem cell line (iPSC) from a PCOS patient. This disease-specific iPSC line will be beneficial to study PCOS in vitro, allowing to understand the pathogenic mechanisms and a cell-based model for drug development for PCOS. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Jiang X, Hu R, Li C, Xu X, Zhou P, Cao Y, Wang J, Wei Z
Journal Stem cell research
Publication Date 2022 Aug;63:102875
PubMed 35914484
DOI 10.1016/j.scr.2022.102875

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