Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty


Central precocious puberty (CPP) refers to a pediatric endocrine disease in which boys have secondary sexual characteristics before the age of 9 and girls before the age of 8. In this study, we generated an induced pluripotent stem cell line FDCHi006-A from the Peripheral blood cell of a typical central precocious patient who was only 7 years old. This iPSC line showed full pluripotency, normal karyotype and differentiation capacity without integrating vectors. It provides a useful model to study the underlying molecular mechanisms of CPP. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Fan T, He J, Wang Y, Yu J, Sun W
Journal Stem cell research
Publication Date 2021 Oct;56:102542
PubMed 34619645
DOI 10.1016/j.scr.2021.102542

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