Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from testicular fibroblasts
Summary
Curative bone marrow transplantation (BMT) therapies for sickle cell disease (SCD) can cause infertility. The Fertility Preservation Program (FPP) in Pittsburgh cryopreserves testicular tissues for SCD patients prior to BMT in anticipation that those tissues can be thawed in the future and matured to produce sperm. Here, we generated and validated two isogenic patient-derived induced pluripotent stem cell (iPSC) lines from testicular biopsy fibroblasts of a 12-year-old SCD patient. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Harancher MR, Sukhwani M, Castro CA, Hsieh MH, Orwig KE |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103257 |
| PubMed | 38000347 |
| PubMed Central | PMC10845156 |
| DOI | 10.1016/j.scr.2023.103257 |