JMUi001-A

Registration Summary:

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General

iPSC Line
hPSCreg name	JMUi001-A
Cite as:	JMUi001-A (RRID:CVCL_ZL58)
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	No similar lines found.
Last update	2nd April 2020
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Provider
Generator	Institute of Anatomy (University of Würzburg) (JMU)
External iPSC Databases
Cellosaurus	CVCL_ZL58
Wikidata	Q98126796
General iPSC Information
Publications	Kwok CK et al. Scalable stirred suspension culture for the generation of billions of human induced pluripotent stem cells using single-use bioreactors. Journal of tissue engineering and regenerative medicine. 2018 Feb;12(2):e1076-e1087. Janz A et al. Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation. Stem cell research. 2020 Jul;46:101856. Wasmus C et al. Metabolic Alterations Caused by Defective Cardiolipin Remodeling in Inherited Cardiomyopathies. Life (Basel, Switzerland). 2020 Nov 11;10(11). Jansch C et al. Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. Journal of neural transmission (Vienna, Austria : 1996). 2021 Feb;128(2):225-241. Janz A et al. CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM). Stem cell research. 2021 May;53:102256. McKnight CL et al. Modelling Mitochondrial Disease in Human Pluripotent Stem Cells: What Have We Learned?. International journal of molecular sciences. 2021 Jul 20;22(14). GÜLER KARA Hale et al. CRISPR-Cas Functional Genetic Screening: Traditional Review. Turkiye Klinikleri Journal of Medical Sciences. 2022-00-00. Kumari D et al. Hsp40s play distinct roles during the initial stages of apolipoprotein B biogenesis. Molecular biology of the cell. 2022 Feb 1;33(2):ar15. Popoiu TA et al. Cardiac Involvement in Mitochondrial Disorders. Current heart failure reports. 2023 Feb;20(1):76-87. Walz K et al. Generation of a CRISPR/Cas9-edited Plakoglobin (JUP) knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy. Stem cell research. 2023 Dec;73:103240. Janz A et al. Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes. Molecular metabolism. 2024 Jan;79:101859. Gerritse Merel et al. Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy. Pharmacology & Therapeutics. 2025-08-00. Gramatiuk Svetlana M. et al. Development of an Arrhythmogenic Cardiomyopathy Model Using CRISPR-Cas9 and Homology-Directed Repair. Ukrainian Journal of Cardiovascular Surgery. 2025-09-25. Maack Christoph et al. Mitochondrial cardiomyopathies: pathogenesis, diagnosis, and treatment. European Heart Journal. 2025-10-22. Tisch M et al. Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease. Molecular psychiatry. 2026 May;31(5):2927-2940.
Subclones	JMUi001-A-1 JMUi001-A-2 JMUi001-A-3 JMUi001-A-4

iPSC Derivation

General