Derivation of iPSC lines from two idiopathic ASD patients (OFi001-A, OFi002-A)


Here we described two human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) of idiopathic autism spectrum disorder (ASD) patients through forced expression of OCT4, SOX2, KLF4, and c-MYC. The hiPSC lines displayed morphology, gene expression patterns, and pluripotential differentiation potentials similar to those of human embryonic stem cells (hESCs). The hiPSC lines from idiopathic ASD patients might be useful to unveil the underlying mechanism of idiopathic ASD and finding its therapeutics. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Guo H, Jin ZL, Yao X, Park J, Gwon YP, Kim S, Kim KP, Cui XS, Kim NH, Yoo H, Han DW
Journal Stem cell research
Publication Date 2021 Oct;56:102510
PubMed 34438162
DOI 10.1016/j.scr.2021.102510

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