Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His


Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Oh J, Lee SH, Choi J, Choi JR, Kim S, Cha YJ, Choi HK, Won D, Yoon HG, Park SW, Kang SM, Lee ST, Lee SH
Journal Stem cell research
Publication Date 2021 Oct;56:102508
PubMed 34438160
DOI 10.1016/j.scr.2021.102508

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