Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His
Summary
Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Oh J, Lee SH, Choi J, Choi JR, Kim S, Cha YJ, Choi HK, Won D, Yoon HG, Park SW, Kang SM, Lee ST, Lee SH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Oct;56:102508 |
| PubMed | 34438160 |
| DOI | 10.1016/j.scr.2021.102508 |