Generation of induced pluripotent stem cell GZHMCi002-A from peripheral blood mononuclear cells with APOB mutation

Summary

Apolipoprotein (apo) B is a large, amphipathic glycoprotein which plays an important role in human lipoprotein metabolism. The 43-kb APOB gene located on the short arm of human chromosome 2 and consisted of 29 exons, mutations in the APOB gene can give rise to either hypo- or hypercholesterolemia. We used peripheral blood mononuclear cells (PBMCs) from a volunteer carrying the APOB mutation (c.10579C>T, p.Arg3527Trp) located in exon 9 to establish induced pluripotent stem cells (iPSC), which will be an effective means to reveal the key biologically relevant metabolic mechanisms, a powerful tool for medicine selection and related research. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Bing S, Nengqing L, Yi C, Dian L, Diyu C, Yingjun X, Lina H, Yinghong Y, Hongmei G, Xiaofang S
Journal Stem cell research
Publication Date 2020 Oct 16;49:102054
PubMed 33128957
DOI 10.1016/j.scr.2020.102054

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