Generation of a human iPSC line (CHCMUi002-A) from peripheral blood mononuclear cells from a chronic granulomatous disease patient
Summary
Chronic granulomatous disease (CGD) is a rare X-linked recessive primary immunodeficiency disease (PID). Herein, a human induced pluripotent stem cell (iPSC) line was generated from the peripheral blood mononuclear cells (PBMCs) of a CGD patient with a mutation (c.785_786delTT) in the CYBB gene. These iPSCs showed the expression of pluripotency markers, the ability to differentiate into three germ layers. They offer a promising technique for studying the pathogenesis and conducting drug screening for CGD patients. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zeng A, Ni K, Fang S, Yu L, Gao Y, Zhou L, Zhao X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Feb;74:103269 |
| PubMed | 38134578 |
| DOI | 10.1016/j.scr.2023.103269 |