CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
Summary
We confirmed that gene haploinsufficiency is the mechanism for the dominant pathogenicity of CRX and discovered that CRX regulated postmitotic photoreceptor precursor translocation in addition to its specification of photoreceptor cell fates during human retinal development. These findings revealed a new underlying mechanism of CRX dominant pathogenesis and provided a new clue for the treatment of CRX-associated human retinopathies. © 2023. The Author(s).
| Authors | Pan D, Zhang X, Jin K, Jin ZB |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2023 Dec 5;14(1):346 |
| PubMed | 38049871 |
| PubMed Central | PMC10696917 |
| DOI | 10.1186/s13287-023-03590-3 |