Generation of two additional integration-free iPSC lines from related human donors


The integration-free iPSC lines TISSUi006-A and TISSUi007-A were generated by reprogramming blood cells with episomal vectors. The male human donors belong to a Caucasian family in which four additional family members donated and iPSC lines were generated. All iPSC lines within this family are approved for commercial use by donor consent. Those iPSC lines offer the opportunity to study the influence of affiliation within one family. In future, more iPSCs lines of many more family members can be created to understand the effects of relatives with different ages on the reprogramming into iPSCs and differentiation into specific cell types. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Ramme AP, Faust D, Koenig L, Nguyen N, Marx U
Journal Stem cell research
Publication Date 2021 May;53:102327
PubMed 33901815
DOI 10.1016/j.scr.2021.102327

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