Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations


Huntington's disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive, and behavioral dysfunctions associated with HD. In addition to this, their chronic use is limited by their long-term side effects. Herbal drugs offer a plausible alternative to this and have shown substantial therapeutic effects against HD. Moreover, their safety profile is better in terms of side effects. However, due to limited drug solubility and permeability to reach the target site, herbal drugs have not been able to reach the stage of clinical exploration. In recent years, the paradigm of research has been shifted towards the development of herbal drugs based nanoformulations that can enhance their bioavailability and blood-brain barrier permeability. The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers, along with their potential neuroprotective effects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Authors Vishwas S, Gulati M, Kapoor B, Gupta S, Singh SK, Awasthi A, Khan A, Goyal A, Bansal A, Baishnab S, Singh TG, Arora S, Porwal O, Kumar A, Kumar V
Journal Current neuropharmacology
Publication Date 2021;19(7):957-989
PubMed 33167841
PubMed Central PMC8686322
DOI 10.2174/1570159x18666201109090824

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