Functional assessment of donated human embryos for the generation of pluripotent embryonic stem cell lines


None of the donated blastocysts with poor morphological quality in association with genetic abnormalities detected by NGS had the capacity for further in-vitro expansion to originate pluripotent HESC lines. This finding seems to provide extra support to genetic counselling on the suitability of this type of embryo for clinical use. Copyright © 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Authors Ceschin II, Ceschin AP, Joya MS, Mitsugi TG, Nishikawa LK, Krepischi AC, Okamoto OK
Journal Reproductive biomedicine online
Publication Date 2022 Dec 2;
PubMed 36737274
DOI 10.1016/j.rbmo.2022.11.020

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