Analysis of chromosome microstructures in products of conception associated with recurrent miscarriage


High-resolution genome-wide SNP arrays are effective for detecting novel genetic factors causing recurrent miscarriage. A more appropriate reference CNV list may be necessary to more effectively enrich for CNV likely to cause recurrent miscarriage. The findings confirmed one non-coding RNA cluster as a strong candidate that may contribute to unexplained miscarriages. Gene expression-regulatory mechanisms may play important roles in the pathogenesis of miscarriages. Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Authors Sato T, Migita O, Hata H, Okamoto A, Hata K
Journal Reproductive biomedicine online
Publication Date 2019 May;38(5):787-795
PubMed 30926177
DOI 10.1016/j.rbmo.2018.12.010

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