Analysis of chromosome microstructures in products of conception associated with recurrent miscarriage
Summary
High-resolution genome-wide SNP arrays are effective for detecting novel genetic factors causing recurrent miscarriage. A more appropriate reference CNV list may be necessary to more effectively enrich for CNV likely to cause recurrent miscarriage. The findings confirmed one non-coding RNA cluster as a strong candidate that may contribute to unexplained miscarriages. Gene expression-regulatory mechanisms may play important roles in the pathogenesis of miscarriages. Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
| Authors | Sato T, Migita O, Hata H, Okamoto A, Hata K |
|---|---|
| Journal | Reproductive biomedicine online |
| Publication Date | 2019 May;38(5):787-795 |
| PubMed | 30926177 |
| DOI | 10.1016/j.rbmo.2018.12.010 |