Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening


In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Hunter ZL, Leeson HC, Shaker MR, Wolvetang EJ, Vadlamudi L
Journal Stem cell research
Publication Date 2022 Apr;60:102673
PubMed 35074713
DOI 10.1016/j.scr.2022.102673

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