Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer's Disease


Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Schöndorf DC, Elschami M, Schieck M, Ercan-Herbst E, Weber C, Riesinger Y, Kalman S, Steinemann D, Ehrnhoefer DE
Journal Stem cell research
Publication Date 2019 Jan;34:101351
PubMed 30611016
DOI 10.1016/j.scr.2018.11.012

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