Generation of a human iPSC line, IISHDOi002-A, with a 46, XY/47, XYY mosaicism and belonging to an African mitochondrial haplogroup

Summary

We have generated a human iPSC line, IISHDOi002-A, from commercial primary normal human dermal fibroblasts belonging to an African mitochondrial haplogroup (L3), and with a 46, XY/47, XYY mosaicism. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4 and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Ortuño-Costela MDC, Moreno-Izquierdo A, Garesse R, Gallardo ME
Journal Stem cell research
Publication Date 2018 Apr;28:131-135
PubMed 29471262
DOI 10.1016/j.scr.2018.02.009

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