Generation of a human iPSC line, IISHDOi002-A, with a 46, XY/47, XYY mosaicism and belonging to an African mitochondrial haplogroup
Summary
We have generated a human iPSC line, IISHDOi002-A, from commercial primary normal human dermal fibroblasts belonging to an African mitochondrial haplogroup (L3), and with a 46, XY/47, XYY mosaicism. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4 and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Ortuño-Costela MDC, Moreno-Izquierdo A, Garesse R, Gallardo ME |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2018 Apr;28:131-135 |
| PubMed | 29471262 |
| DOI | 10.1016/j.scr.2018.02.009 |