Superoxide dismutase 2 ameliorates mitochondrial dysfunction in skin fibroblasts of Leber's hereditary optic neuropathy patients
Summary
SOD2 upregulation inhibited cells apoptosis through ameliorating mitochondrial dysfunction and reducing NF-κB associated inflammatory response. This study further support exogenous SOD2 may be a promising therapy for the treatment of LHON. Copyright © 2022 Zhou, Yao, Yang, Guo, Li, Li and Lei.
| Authors | Zhou Q, Yao S, Yang M, Guo Q, Li Y, Li L, Lei B |
|---|---|
| Journal | Frontiers in neuroscience |
| Publication Date | 2022;16:917348 |
| PubMed | 36017189 |
| PubMed Central | PMC9398213 |
| DOI | 10.3389/fnins.2022.917348 |