Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene
Summary
Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin-myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A-an established iPSC-could be useful for the investigation of DCM. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Jeon SB, Kim H, Chun KH, Oh J, Kwon C, Choi HK, Kim S, Kim HP, Kim IC, Yoo JY, Park SW, Kang SM, Lee SH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Mar;67:103048 |
| PubMed | 36801602 |
| DOI | 10.1016/j.scr.2023.103048 |