Generation of induced pluripotent stem cell line derived from FNAIT patient with CD36 deficiency mutations


Fetal and neonatal alloimmune thrombocytopenia (FNAIT) caused by anti-CD36 isoantibodies is a common disease and the frequency of type I CD36 deficiency is relatively high in eastern Asian populations.Currently, patient-specific induced pluripotent stem cells (hiPSC) are believed to be useful tools for studying anti-CD36 mediated FNAIT and finding new therapeutic approaches to the disease.We generated an iPSC line from peripheral blood mononuclear cells of a patient carrying a 329-330delAC of the CD36 gene.The iPSC expressed pluripotency markers, gave rise to derivatives of three germ layers during spontaneous differentiation, had a normal karyotype, and retained the patient-specific mutation. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Chen D, Wang T, Ye X, Xu X, Xia W, Fu Y
Journal Stem cell research
Publication Date 2022 May;61:102749
PubMed 35305469
DOI 10.1016/j.scr.2022.102749

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