Generation of induced pluripotent stem cells (NJDTHi001-A) from a Danon disease child with mutation of c.467 T > G in LAMP2 gene

Summary

The induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from a male child with Danon disease. Next-generation sequencing (NGS) revealed a stop gained mutation c.467 T > G in LAMP2 gene. PBMCs were reprogrammed by using non-integrating Sendai reprogramming kits. It is a possible cell model to screen alternative medicine treatment of the Danon disease. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zhu X, Wang J, Chong H, Wang J, Wang D
Journal Stem cell research
Publication Date 2020 Sep 23;49:101994
PubMed 33038746
DOI 10.1016/j.scr.2020.101994

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