Generation of induced pluripotent stem cells (NJDTHi001-A) from a Danon disease child with mutation of c.467 T > G in LAMP2 gene
Summary
The induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from a male child with Danon disease. Next-generation sequencing (NGS) revealed a stop gained mutation c.467 T > G in LAMP2 gene. PBMCs were reprogrammed by using non-integrating Sendai reprogramming kits. It is a possible cell model to screen alternative medicine treatment of the Danon disease. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhu X, Wang J, Chong H, Wang J, Wang D |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:101994 |
| PubMed | 33038746 |
| DOI | 10.1016/j.scr.2020.101994 |