Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder


Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD and reprogrammed with the human SKOM transcription factors. The patient has a heterozygous C > T mutation of FCGR1B gene that was confirmed by sequencing analysis. The pluripotency was verified by gene expression and capacity of differentiation towards the three germ layers. This kind of iPSC will be valuable for further understanding the pathogenesis of ASD and help to develop drugs for treating ASD. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Li S, Zhao H, Huang R, He L, Tian C, Huang H, Han X, Tang F, Lin Z, Deng S, Zhou J, Li Z
Journal Stem cell research
Publication Date 2019 Oct;40:101571
PubMed 31520889
DOI 10.1016/j.scr.2019.101571

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