Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
Summary
During early neuronal differentiation, there are consistent and time-point specific proteomic alterations in RTT patient cells carrying exons 3-4 deletion in MECP2. We found changes in proteins involved in pathway associated with RTT phenotypes, including dendrite morphology and synaptogenesis. Our results provide a valuable resource of proteins and pathways for follow-up studies, investigating common mechanisms involved during early disease stages of RTT syndrome.
| Authors | Varderidou-Minasian S, Hinz L, Hagemans D, Posthuma D, Altelaar M, Heine VM |
|---|---|
| Journal | Molecular autism |
| Publication Date | 2020 May 27;11(1):38 |
| PubMed | 32460858 |
| PubMed Central | PMC7251722 |
| DOI | 10.1186/s13229-020-00344-3 |