Generation of an integration-free induced pluripotent stem cell line (UNC001-A) from blood of a healthy individual


Induced pluripotent stem cells (iPSCs) generated from young, healthy individuals are valuable tools for investigating molecular disease mechanisms during the early development of the brain vasculature. We generated an iPSC line from peripheral blood mononuclear cells (PBMCs) isolated from a healthy 13-yeard old female donor using the Sendai virus. The iPSCs differentiated into endothelial cells, astrocytes, and neurons. This iPSC line can serve as a healthy reference control for comparative studies in drug development and modeling the early onset of Cerebral Cavernous Malformation (CCM). Copyright © 2020. Published by Elsevier B.V.

Authors Molina SG, Beltran AA, Beltran AS
Journal Stem cell research
Publication Date 2020 Dec;49:102015
PubMed 33038744
DOI 10.1016/j.scr.2020.102015

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