Generation of an induced pluripotent stem cell line GZHMCi008-A derived from a patient with SRY-positive 46,XX testicular disorder of sex development

Summary

The testicular disorder of sex development (TDSD) is a rare condition characterized by a male appearance with a female karyotype. The most frequent cause of TDSD is misplacement of the sex determining region Y (SRY) gene on the X chromosome. Here, we report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a patient with SRY-positive 46,XX TDSD. This cell line offers an unprecedented cellular model to investigate the profound manifestations like infertility of the male sex reversal patients, and serves as a useful tool to develop therapies for the disease. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Luo Y, Chen Y, Zhang M, Ma X, Zhu D, Chen Y
Journal Stem cell research
Publication Date 2021 Oct 22;57:102583
PubMed 34710837
DOI 10.1016/j.scr.2021.102583

Research Projects

Cell Lines