Generation of an induced pluripotent stem cell line GZHMCi008-A derived from a patient with SRY-positive 46,XX testicular disorder of sex development
Summary
The testicular disorder of sex development (TDSD) is a rare condition characterized by a male appearance with a female karyotype. The most frequent cause of TDSD is misplacement of the sex determining region Y (SRY) gene on the X chromosome. Here, we report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a patient with SRY-positive 46,XX TDSD. This cell line offers an unprecedented cellular model to investigate the profound manifestations like infertility of the male sex reversal patients, and serves as a useful tool to develop therapies for the disease. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Luo Y, Chen Y, Zhang M, Ma X, Zhu D, Chen Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Dec;57:102583 |
| PubMed | 34710837 |
| DOI | 10.1016/j.scr.2021.102583 |