Episomal vector-based generation of human induced pluripotent stem cell line MUSIi020-A from peripheral blood T-cells


Human induced pluripotent stem cell (iPSC) line MUSIi020-A was generated from T cells isolated from peripheral blood of a healthy 37-year-old female and reprogrammed using episomal plasmid vectors. The established transgene-free MUSIi020-A, which retained a normal karyotype, displayed pluripotency as characterized by expression of pluripotency markers and by in vitro spontaneous differentiation toward three embryonic germ layers. This cell line may represent a valuable tool for studying T cell development and a potential cell source for cancer immunotherapy. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Pratumkaew P, Luanpitpong S, Klaihmon P, Lorthongpanich C, Laowtammathron C, Meesa S, Suksomboon W, Issaragrisil S
Journal Stem cell research
Publication Date 2022 Oct;64:102929
PubMed 36183677
DOI 10.1016/j.scr.2022.102929

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