Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system
Summary
This work demonstrates an efficient method for generating hiPSC KI lines and the description of a new 3D model to study OL differentiation, migration, and maturation both during in vitro neurodevelopment as well as in response to environmental chemicals or disease-associated stressors. Copyright © 2023 Romero, Berlinicke, Chow, Duan, Wang, Chamling and Smirnova.
| Authors | Romero JC, Berlinicke C, Chow S, Duan Y, Wang Y, Chamling X, Smirnova L |
|---|---|
| Journal | Frontiers in cellular neuroscience |
| Publication Date | 2022;16:1094291 |
| PubMed | 36744062 |
| PubMed Central | PMC9893511 |
| DOI | 10.3389/fncel.2022.1094291 |