Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation
Summary
Leucine-rich repeat kinase 2 (LRRK2), also known as Dardarin (derived from the Basque word "dardara," meaning tremor), is a protein kinase encoded by the PARK8 gene. This protein is mainly distributed in the cytoplasm; however, it is also present in the mitochondrial outer membrane. Mutations in the LRRK2 protein cause Parkinson's disease (PD). We generated a human induced pluripotent stem cell (iPSC) line (CIBi014-A) expressing pluripotency markers. This cell line exhibited a normal karyotype and could be differentiated into three germ layers in vitro. This line will be valuable for investigating the mechanism underlying PD and identifying potential therapeutic targets. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Li L, Si X, Yang J, Lei M, Liu H, Ruan J, Fu H, Li W, Yang H, Lei X, Sang H |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Feb;66:102995 |
| PubMed | 36528012 |
| DOI | 10.1016/j.scr.2022.102995 |