Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation


Leucine-rich repeat kinase 2 (LRRK2), also known as Dardarin (derived from the Basque word "dardara," meaning tremor), is a protein kinase encoded by the PARK8 gene. This protein is mainly distributed in the cytoplasm; however, it is also present in the mitochondrial outer membrane. Mutations in the LRRK2 protein cause Parkinson's disease (PD). We generated a human induced pluripotent stem cell (iPSC) line (CIBi014-A) expressing pluripotency markers. This cell line exhibited a normal karyotype and could be differentiated into three germ layers in vitro. This line will be valuable for investigating the mechanism underlying PD and identifying potential therapeutic targets. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Li L, Si X, Yang J, Lei M, Liu H, Ruan J, Fu H, Li W, Yang H, Lei X, Sang H
Journal Stem cell research
Publication Date 2022 Dec 9;66:102995
PubMed 36528012
DOI 10.1016/j.scr.2022.102995

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