Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D6*10/CYP3A5*3C and CYP2D6*10/CYP2C19*2
Summary
Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These hiPSC lines can serve as valuable resources for expanding our understanding of the relationships between genotypes and drug reactions. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lee J, Kim G, Chi KY, Han C, Kim JH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102970 |
| PubMed | 36399926 |
| DOI | 10.1016/j.scr.2022.102970 |