Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype


Apolipoprotein E ε4 allele (APOE4) is a minor allele of the APOE gene associated with a higher risk for Alzheimer's Disease (AD) and Vascular Dementia (VD). While lipid deposition and chronic inflammation in glia are the commonalities between atherosclerosis, VD, and AD. Hence, we presented an iPSC line of an AD male donor suffering from Cerebrovascular Atherosclerosis with APOE-ε4/ε4 alleles background. Furthermore, we differentiated the iPSCs into astrocyte to explore pathogenesis in APOE4 related dementia. The characterized iPSC line expressed typical pluripotency markers and showed differentiation potential and normal karyotype. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Ma X, Ma J, Guo R, Du J, Feng B, Liu X, Du X, Ma Z, Cui H
Journal Stem cell research
Publication Date 2021 Jul;54:102450
PubMed 34218115
DOI 10.1016/j.scr.2021.102450

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