Generation and characterization of a human induced pluripotent stem cell line (XWHNi001-A) derived from an Alzheimer's disease patient with mutation in the APP gene


Mutations in the APP gene are popularly known as the second cause trigger the familial Alzheimer's disease (AD). We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from an AD patient using non-integrative Sendai virus. The iPSC line highly expresses pluripotency markers, has the capacity to differentiate into the normal teratoma tissue, retains the APP mutation, and displays the normal karyotype. The iPSC line will provide a useful resource to study the pathogenesis and drugs screening of AD. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wei C, Lu X, Zou Q, Gong S, Chen Y, Lyu J, Jia J
Journal Stem cell research
Publication Date 2022 Apr;60:102690
PubMed 35149456
DOI 10.1016/j.scr.2022.102690

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