Generation of induced pluripotent stem cells from a patient with X-linked juvenile retinoschisis


X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy manifested as splitting of anatomical layers of retina. In this report, we generated a patient-specific induced pluripotent stem cell (iPSC) line, TVGH-iPSC-013-05, from the peripheral blood mononuclear cells of a male patient with XLRS by using the Sendai-virus delivery system. We believe that XLRS patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease. Copyright © 2018. Published by Elsevier B.V.

Authors Peng CH, Huang KC, Lu HE, Syu SH, Yarmishyn AA, Lu JF, Buddhakosai W, Lin TC, Hsu CC, Hwang DK, Shen CN, Chen SJ, Chiou SH
Journal Stem cell research
Publication Date 2018 May;29:152-156
PubMed 29674172
DOI 10.1016/j.scr.2018.04.005

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