Generation of two induced pluripotent stem cell lines from psoriatic patient with cardiovascular comorbidity


Psoriasis (Ps) is a chronic, inflammatory skin disease characterized by thickened, red and scaly plaques. Systemic inflammation associated with psoriasis results in an increased risk of death due to the development of psoriasis-associated comorbidities such as cardiovascular disease (CVD) and metabolic syndrome. Although the cardiometabolic features in psoriasis are clinically well described, the underlying molecular mechanisms linking these comorbidities remain poorly understood. Generation of induced pluripotent stem cells (hiPSCs) from peripheral blood mononuclear cells (PBMCs) and skin fibroblasts (SFs) of psoriatic patients provides a novel approach to investigate the pathway by which cutaneous inflammation promotes CV complications in this disorder. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Dev E, Adamska P, Wolnik J, Oleksy A, Piętowska Z, Zalewski A, Maj J, Dulak J, Biniecka M
Journal Stem cell research
Publication Date 2023 Dec;73:103251
PubMed 37979431
DOI 10.1016/j.scr.2023.103251

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