Establishment of a new human iPSC cell line (UOMi012-A) from a patient with congenital heart defect who has undergone Fontan procedure
Summary
Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surgeries leading to completion of Fontan circulation at the age of 13yr., and this line was generated when she was 38yr. old. The exact genetic cause of this patient's congenital heart defect is unknown, and this line will be used for studying molecular and cellular mechanisms responsible for cardiac dysfunction, along with screening for future potential therapeutic avenues. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Sareen N, Srivastava A, Mittal I, Shah AH, Dhingra S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Oct;80:103509 |
| PubMed | 39089181 |
| DOI | 10.1016/j.scr.2024.103509 |