LUMCi030-A-1

iso03LUMC0110iALK04

General

Cell Line

hPSCreg name LUMCi030-A-1
Cite as:
LUMCi030-A-1 (RRID:CVCL_ZL47)
Alternative name(s)
iso03LUMC0110iALK04
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
LUMCi030-B-1
(iso01LUMC0110iALK10)
Donor diseases:
Hereditary Hemorrhagic Telangiectasia
LUMCi030-A
(LUMC0110iALK04)
Donor diseases:
Hereditary Hemorrhagic Telangiectasia
LUMCi030-B
(LUMC0110iALK10)
Donor diseases:
Hereditary Hemorrhagic Telangiectasia
KMUGMCi001-A
(KMUGMCi001ACVRL1)
Donor diseases:
Telangiectasia, Hereditary Hemorrhagic
Last update 19th March 2020
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Provider

Generator Leiden University Medical Center (LUMC)

External Databases

BioSamples SAMEA6712312
Cellosaurus CVCL_ZL47
Wikidata Q98127101

General Information

Publications
* Is the cell line readily obtainable for third parties?
No
Subclone of

Donor Information

General Donor Information

Sex male

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • Telangiectasia, Hereditary Hemorrahagic, of Rendu, Osler
  • Osler-Weber-Rendu Disease
  • Hereditary Hemorrhagic Telangiectasia
  • Hereditary hemorrhagic telangiectasia
show more synonyms

Donor Relations

Other cell lines of this donor

External Databases (Donor)

BioSamples SAMEA6712311

Ethics

Also have a look at the ethics information for the parental line LUMCi030-A .
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

The source cell information can be found in the parental cell line LUMCi030-A.
Passage number reprogrammed 3

Reprogramming method

Vector type Integrating
Vector Plasmid
Is the used vector excisable?
Unknown
Absence of reprogramming vector(s)?
Unknown
Reprogramming vectors silenced?

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium TeSR™ E8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
NANOG
Yes
SSEA-4
Yes
POU5F1 (OCT-4)
Yes
Morphology pictures
Differentiation Potency
Ectoderm
Ont Id: UBERON_0000924
In vitro directed differentiation
Marker Expressed
TUBB3
Yes
PAX6
Yes

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XY

Other Genotyping (Cell Line)

Genetic Modification

Disease/phenotype related modifications
Synonyms
  • Telangiectasia, Hereditary Hemorrahagic, of Rendu, Osler
  • Osler-Weber-Rendu Disease
  • Hereditary Hemorrhagic Telangiectasia
  • Hereditary hemorrhagic telangiectasia
show more synonyms
Genetic modifications
ACVRL1 (target)
Isogenic modification
Heterozygous
Repaired