Role of YAP in hematopoietic differentiation and erythroid lineage specification of human-induced pluripotent stem cells
Summary
Expression of YAP is crucial for the differentiation of hiPSC-derived HSPCs toward mature erythrocytes. We believe that by manipulating YAP activity using small molecules, the efficiency of the large-scale in vitro production system for generating hematopoietic stem/progenitor cells for future therapeutic use could be improved. © 2023. BioMed Central Ltd., part of Springer Nature.
| Authors | Laowtammathron C, Lorthongpanich C, Jiamvoraphong N, Srisook P, Klaihmon P, Kheolamai P, Luanpitpong S, Issaragrisil S |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2023 Sep 29;14(1):279 |
| PubMed | 37775798 |
| PubMed Central | PMC10543272 |
| DOI | 10.1186/s13287-023-03508-z |