Generation of induced pluripotent stem cells (NIMHi004-A, NIMHi005-A and NIMHi006-A) from healthy individuals of Indian ethnicity with no mutation for Parkinson's disease related genes


This study describes the generation and characterization of 3 induced pluripotent stem cell lines (iPSCs) generated by somatic reprogramming of peripheral blood mononuclear cells (PBMCs) obtained from healthy individuals. The reprogramming was carried out using non-integrating Sendai virus vectors expressing hKOS, hc-myc and hKlf4. The donors did not carry any mutations for a panel of 13 genes associated with occurrence and progression of Parkinson's disease (PD). These iPSC lines serve as age and gender matched control for the PD patient derived iPSC lines reported by us previously (Datta et al., 2020), neither did the samples have any chromosomal abnormalities. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Jagtap S, Sowmithra, Yadav R, Pal PK, Datta I
Journal Stem cell research
Publication Date 2022 Apr;60:102716
PubMed 35220026
DOI 10.1016/j.scr.2022.102716

Research Projects

Cell Lines