SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier
Summary
Our study shows that the BCSFB of the ChP rather than the BBB is susceptible to direct SARS-CoV-2 infection. Thus, neuropsychiatric symptoms because of COVID-19 may rather be associated with dysfunction of the BCSFB than the BBB. Future studies should consider a role of the ChP in underlying neuropsychiatric symptoms following SARS-CoV-2 infection. © 2023. BioMed Central Ltd., part of Springer Nature.
| Authors | Stüdle C, Nishihara H, Wischnewski S, Kulsvehagen L, Perriot S, Ishikawa H, Schroten H, Frank S, Deigendesch N, Du Pasquier R, Schirmer L, Pröbstel AK, Engelhardt B |
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| Journal | Fluids and barriers of the CNS |
| Publication Date | 2023 Oct 24;20(1):76 |
| PubMed | 37875964 |
| PubMed Central | PMC10598911 |
| DOI | 10.1186/s12987-023-00479-4 |