An integration-free iPSC line SDQLCHi025-A from a girl with multiminicore disease carrying compound heterozygote mutations in RYR1 gene
Summary
Peripheral blood mononuclear cells for reprogramming in this work were donated by a girl with clinically and genetically diagnosed multiminicore disease harboring compound heterozygote mutations of RYR1 gene. Induced pluripotent stem cells (iPSCs) were obtained by non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and c-MYC. The iPSC line (SDQLCHi025-A) presented pluripotent cell morphology, high mRNA levels of pluripotency markers, differentiation potential in vitro, a normal karyotype, and carrying RYR1 gene mutations. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhang H, Ma Y, Lv Y, Wan Y, Zhao Q, Gai Z, Liu Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 May;45:101775 |
| PubMed | 32272370 |
| DOI | 10.1016/j.scr.2020.101775 |