Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C
Summary
Duchenne muscular dystrophy (DMD) is a severe and rapidly progressive hereditary muscular disease with X-linked recessive inheritance, occurring mainly in males. A complete loss of dystrophin resulted from out-of-frame deletion mutations in the DMD gene leads to Duchenne muscular dystrophy. DMD induced pluripotent stem cells (iPSCs) are a suitable cell model to study muscle development and disease mechanisms underlying muscular dystrophy and to screen novel compounds with potential therapeutic effects. We generated iPSCs from a DMD patient using non-integrating episomal plasmid vectors. The obtained iPSC lines showed ESC-like morphology, expression pluripotency markers, displayed a normal karyotype and possessed trilineage differentiation potential. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Valetdinova KR, Maretina MA, Vyatkin YV, Perepelkina MP, Egorova AA, Baranov VS, Kiselev AV, Gershovich PM, Zakian SM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Oct;48:101941 |
| PubMed | 32777771 |
| DOI | 10.1016/j.scr.2020.101941 |