Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C


Duchenne muscular dystrophy (DMD) is a severe and rapidly progressive hereditary muscular disease with X-linked recessive inheritance, occurring mainly in males. A complete loss of dystrophin resulted from out-of-frame deletion mutations in the DMD gene leads to Duchenne muscular dystrophy. DMD induced pluripotent stem cells (iPSCs) are a suitable cell model to study muscle development and disease mechanisms underlying muscular dystrophy and to screen novel compounds with potential therapeutic effects. We generated iPSCs from a DMD patient using non-integrating episomal plasmid vectors. The obtained iPSC lines showed ESC-like morphology, expression pluripotency markers, displayed a normal karyotype and possessed trilineage differentiation potential. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Valetdinova KR, Maretina MA, Vyatkin YV, Perepelkina MP, Egorova AA, Baranov VS, Kiselev AV, Gershovich PM, Zakian SM
Journal Stem cell research
Publication Date 2020 Oct;48:101941
PubMed 32777771
DOI 10.1016/j.scr.2020.101941

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