Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons
Summary
We describe for the first time the impact of the p.D620N VPS35 mutation on autophago-lysosome pathway and mitochondrial function in stem cell-derived neurons from an affected p.D620N carrier and define neuronal phenotypes for future pharmacological interventions. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
| Authors | Hanss Z, Larsen SB, Antony P, Mencke P, Massart F, Jarazo J, Schwamborn JC, Barbuti PA, Mellick GD, Krüger R |
|---|---|
| Journal | Movement disorders : official journal of the Movement Disorder Society |
| Publication Date | 2021 Mar;36(3):704-715 |
| PubMed | 33142012 |
| PubMed Central | PMC8048506 |
| DOI | 10.1002/mds.28365 |