UMi028-A-2

Registration Summary:

A P E C

TTC3 clone 50

The cell line is not submitted yet.

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General

Cell Line
hPSCreg Name	UMi028-A-2
Alternative name(s)	TTC3 clone 50
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	17th June 2022
User feedback	Written by on No feedback available yet. Login to share your feedback, experiences or results with the research community.
Provider
Generator	University of Miami - Miller School of Medicine (UM) Contact: University of Miami - Miller School of Medicine (UM)
External Databases
Cellosaurus	CVCL_A5QS
Wikidata	Q107117326
General Information
Publications	Lu L et al. Application of CRISPR/Cas9 in Alzheimer's Disease. Frontiers in neuroscience. 2021;15:803894. Potjewyd FM et al. Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function. Frontiers in cellular neuroscience. 2021;15:768655. Laverde-Paz MJ et al. Derivation of stem cell line UMi028-A-2 containing a CRISPR/Cas9 induced Alzheimer's disease risk variant p.S1038C in the TTC3 gene. Stem cell research. 2021 Apr;52:102258. Sen T et al. CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics. Neurotoxicity research. 2022 Oct;40(5):1597-1623. Mollashahi B et al. Research and Therapeutic Approaches in Stem Cell Genome Editing by CRISPR Toolkit. Molecules (Basel, Switzerland). 2023 Feb 20;28(4). Wong Poh Kuan et al. The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells. The CRISPR Journal. 2023-06-01. Cukier Holly N. et al. An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons. Neurobiology of Aging. 2023-11-00.
Subclone of	UMi028-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line UMi028-A.