Generation of ZJUi003-A, an induced pluripotent stem cell line from a Wilson's disease patient carrying a c.180_181del mutation in ATP7B gene


Wilson's disease (WD) is an inherited autosomal recessive disease, which is caused by the mutation of ATP7B gene encoding copper-transporting ATPase protein. The WD patients always suffer from the excessive copper deposition in the liver and other tissues because of the dysfunction of the copper-transporting ATPase protein. In this study, we generated a patient-specific induced pluripotent stem cell (iPSC) line (ZJUi003-A), which showed normal karyotype, expressed pluripotency markers and was capable to differentiate into three germ layers. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang J, Su J, Gong T, Li T, Shen J, Wang H, Xie H, Zhou L, Zheng S, Liang P
Journal Stem cell research
Publication Date 2020 Jul;46:101873
PubMed 32534167
DOI 10.1016/j.scr.2020.101873

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