Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient

Summary

A new induced pluripotent stem cell (iPSC) line namely UOMi008-A was generated from a patient having a childhood onset of Hypophosphatasia (HPP). This patient has compound heterozygous mutations c.571G > A (p.Glu191Lys) and c.1001G > A (p.Gly334Asp) in the ALPL gene respectively. This iPSC line will be used for in vitro disease modeling, which will aid in delineating the underlying molecular mechanism involved in disease pathogenesis and provide plausible new therapeutic directions. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Srivastava A, Verma E, Rockman-Greenberg C, Dhingra S
Journal Stem cell research
Publication Date 2022 Aug 9;64:102891
PubMed 35964540
DOI 10.1016/j.scr.2022.102891

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