Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells
Summary
iPSCs engineered with CARs, including the established single-cell clone CAR-TIM3 iPSCs herein, are potential alternative cell source for generating off-the-shelf CAR-NK cells as well as other CAR-immune cells. The feasibility of differentiation of functional CAR-TIM3 NK cells under serum- and feeder-free conditions support that Good Manufacturing Practice (GMP)-compliant protocols can be further established for future clinical applications. © 2023. The Author(s).
| Authors | Klaihmon P, Luanpitpong S, Kang X, Issaragrisil S |
|---|---|
| Journal | Cancer cell international |
| Publication Date | 2023 Nov 27;23(1):297 |
| PubMed | 38012684 |
| PubMed Central | PMC10680184 |
| DOI | 10.1186/s12935-023-03153-9 |